VEGF A165b also prevented hyperglycaemia enhanced TRPA1

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steroid side effects Increased transient receptor potential ankyrin 1 (TRPA1) channel activity is associated with the onset of diabetic neuropathy. VEGF A165b also prevented hyperglycaemia enhanced TRPA1 activity in an in vitro sensory neuronal cell line indicating a novel direct neuronal mechanism that could underlie the anti nociceptive effect observed in vivo. These results demonstrate that in a model of Type I diabetes VEGF A165b attenuates altered pain behaviour and prevents neuronal stress, possibly through an effect on TRPA1 activity.. steroid side effects

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